Scientific Program
Nov 15 - 17, 2023 | Leuven, BelgiumWednesday, November 15th
12:30 am – 2:00 pm
Registration
Check-In + set-up Posters
2:00 PM – 3:15 PM
Opening Lecture
2:00 pm
Welcome
Introduction by Geert Bultynck
2:15 pm
Endoplasmic reticulum biology and Ca2+-release channels
by Jan B. Parys (KU Leuven, Belgium)
Jan B. Parys
3:15 PM – 6:30 PM
Session 1: Ca2+ in pathophysiology
3:15 pm
Introduction
Session chair: Thomas Voets
3:20 pm
Targeting ER signaling as an approach to treat neurodegeneration
by Ilya Bezprozvanny (UT Southwestern Medical Center at Dallas, USA)
Ilya Bezprozvanny
3:50 pm
Calcium signaling and neuropathy
by Barbara Ehrlich (Yale University, USA)
Barbara Ehrlich
4:20 pm
Coffee Break
5:00 pm
Calcium signaling in cancer cells: new challenges
by Natalia Prevarskaya (Universite de Lille, France)
Natalia Prevarskaya
5:30 pm
Selected Short Talk: Mitoception or transfer of normal mitochondria to tumor cells reverses Ca2+ remodeling in colon cancer cells
by Carlos Villalobos (University of Valladolid, Spain)
5:45 pm
Selected Short Talk: Astrocyte store-operated calcium entry is required for the development of chronic neuropathic pain
By Jeremy Smyth (Uniformed Services University of the Health Sciences, USA)
Commercial Partners talks
Session Chair: Geert Bultynck
6:00 pm
CoolLed Sponsored Movie
6:05 pm
Hamamatsu Sponsored Short Talk
Jean Marc D’Angelo (Hamamatsu Photonics, France): Electric Field Stimulation Technique for High-Throughput Screening of Voltage-Gated Ion Channels and Julius Rönkkö (University of Helsinki, Finland): Human IP3 receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism
6:30 pm – 9:30 pm
Opening Beer & Cheese reception
Guided by Dimitri Staelens
Dimitri Staelens
Thursday November 16th
8:30 am – 12:00 pm
Session 2: Novel insights in Ca2+-transport systems
8:30 AM
Introduction
Session Chair: Philippe Gailly and Luc Leybaert
8:35 AM
ORP5/ORP8, phosphatidylserine and STIM1-Orai1 interaction and function
by Shmuel Muallem (NIH, USA)
Shmuel Muallem
9:05 AM
Lessons learned from in vivo measurements of Ca2+ signals in exocrine glands
by David Yule (University of Rochester, USA)
David Yule
9:35 AM
Selected Short Talk: Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional Inositol 1,4,5-trisphosphate receptor subtype 3 defects
by Julika Neumann (KU Leuven, Belgium)
9:50 AM
Selected Short Talk: Adhesion to laminin-1 and collagen IV induces the formation of Ca2+ microdomains that sensitize mouse T cells for activation
by Mariella Weiß (University Medical Centre Hamburg, Germany)
10:05 AM
Coffee Break
10:40 AM
Novel insights in NAADP signaling
by Andreas Guse (University Medical Centre Hamburg, Germany)
Andreas Guse
11:15 AM
Selected Short Talk: Ryanodine receptors regulate ER lysosomal contact and function
by Tim Vervliet (KU Leuven, Belgium)
11:30 AM
Selected Short Talk: Two pore channel 2 (TPC2) activity governs leukocyte adhesion in endothelial cells
by Inga Paules (University of Münster, Germany)
11:45 AM
Selected Short Talk: MASTER-NAADP – Membrane permeAble, Stabilized, biorEversibly pRotected derivative of the Ca2+ mobilizing second messenger NAADP
by Franziska Möckl (University Medical Centre Hamburg, Germany)
12:00 pm – 2:00pm
Sandwich lunch with poster session (Odd Numbers)
2:10 pm – 4:10 pm
Session 3: Cell death and survival
2:10 PM
Introduction
Session Chair: Patrizia Agostinis
2:15 PM
The sophisticated Ca2+toolkit required for the initiation of development in mammals
by Rafael Fissore (University of Massachusetts, USA)
Rafael Fissore
2:45 PM
Selected Short Talk: Pyruvate kinase M2 (PKM2) as a modulator of Ca2+ signaling in cancer cell lines
by Fernanda Lemos (KU Leuven, Belgium)
3:00 PM
Selected Short Talk: Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation
by Christoph Brenker (University of Münster, Germany)
3:15 PM
Selected Short Talk: Going global: How Ca2+ release from lysosomes and the endoplasmic reticulum is coordinated
by Yu Yuan (UC London, UK)
3:30 PM
The Cell Calcium sponsored Keynote lecture: Calcium fluxes in cell death
by Ana Garcia-Saez (University of Cologne, Germany)
Ana Garcia-Saez
4:30 pm – 7:15 pm
Socio-cultural activities or free time
7:30 pm
Dinner at ‘t Oud Gasthuys
Address: Brusselsestraat 63B – Leuven
(Inner Square 30CC near to Roman Gate)
Friday, November 17th
8:30 am – 10:05 am
Session 4: Mitochondrial Ca2+
8:30 AM
Introduction
Session chair: Amalia Dolga
8:35 AM
Licensing of IP3Rs that deliver Ca2+ to mitochondria – a KRAP story
by Peace Atakpa-Adaji (Cambridge University, UK)
Peace Atakpa
9:05 AM
Calcium signalling and organelle contact sites: two interconnected elements in physiological and pathological conditions
by Paola Pizzo (University of Padova, Italy)
Paola Pizzo
9:35 AM
Selected Short Talk : Are TRPV1 channels new players in the reticulum-mitochondrial Ca2+-coupling?
by Sylvie Ducreux (Universite de Lyon, France)
9:50 AM
Selected Short Talk: Novel regulation of IP3 receptors by phosphatidylinositol 4,5-bisphosphate contributes to controlling the transition from local to global Ca2+ signals
by Adelina Ivanova (Cambridge University, UK)
10:05 AM – 10:35 AM
Coffee Break
10:40 am – 12:15 pm
Session 5: Novel insights in Ca2+-binding proteins & effectors
10:40 AM
Introduction
Session chair: Genevieve Dupont
10:45 AM
Molecular segregation of calmodulin mutation phenotypes
by Malene Brohus (Aalborg University, Denmark)
Malene Brohus
11:15 AM
Systematic discovery of calcineurin signaling pathways
by Martha Cyert (Stanford University, USA)
Martha Cyert
11:45 PM
Selected Short Talk: Interplay between axonal mitochondrial transport and neuronal activity.
by Tom Venneman (KU Leuven, Belgium)
12:00 PM
Selected Short Talk: Annexin-A5 is fundamental for VDAC1-dependent mitochondrial Ca2+ homeostasis and determines the susceptibility to apoptosis
by Oflaz Furkan (Medicial University of Graz, Austria)
12:15 PM – 2:15 PM
Sandwich lunch with poster session: even numbers
2:30 PM – 3:40 PM
Session 6: Role of Ca2+ Stores
2:30 PM
Introduction
Session chair: Llew Roderick
2:35 PM
Interplay between stress sensing, signaling and cardiac excitation-contraction (E-C) coupling
by Marek Michalak Michalak (University of Alberta, Canada)
Marek Michalak
3:05 PM
Ca2+ tunneling as an integral modality downstream of SOCE
by Khaled Machaca (Weill Cornell Medical, Qatar)
Khaled Machaca
3:40 PM – 4:45 PM
Closing Session
3:40 PM
Introduction
Session Chair: Jan B. Parys
3:45 PM
Closing Lecture: IP3 receptors and ER-mitochondrial contact sites
by Gyorgy Hajnoczky (Thomas Jefferson University, USA)
Gyorgy Hajnoczky
4:45 PM
Concluding Remarks and Awards
by Geert Bultynck
5:00 PM – 6:30 PM
Closing Reception
8:00 PM – END
Party at Bar Vista, indicate on registration if attending
The day following the conclusion of this workshop there will also be an academic session organized on Saturday November 18th in the afternoon celebrating the retirement of Jan Parys. Workshop attendees and speakers are cordially invited to this session in the University Hallen (Naamsestraat 22). More information about this will be provided later.
Sponsors
Thank you to our sponsors for making this event a success.
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